Osteoblast differentiation

Across TCGA cell cohorts, RNA activity of the Osteoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB20, DYNC2I1, and ZFP69B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoblast differentiation activity versus RAB20 in BLOOD_Leukemia (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RAB20 →	+1.865	+0.196	.001	<.001	3	7
BLOOD_Leukemia	DYNC2I1 →	-0.644	-0.134	<.001	.001	3	6
BLOOD_Leukemia	ZFP69B →	-1.043	-0.242	<.001	<.001	3	5
BLOOD_Leukemia	DDAH2 →	-0.952	-0.116	.003	.007	3	5
BLOOD_Leukemia	RNASET2 →	+1.052	+0.141	.004	<.001	3	5
BONE	TCF3 →	-1.722	-0.354	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001649 vs RAB20 — BLOOD_Leukemia

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