Microtubule bundle formation

Across TCGA patient cohorts, RNA activity of the Microtubule bundle formation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR54, CETN2, and IFT46, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule bundle formation activity versus WDR54 in UCEC (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR54 →	+0.562	+0.131	<.001	<.001	3	8
UCEC	CETN2 →	+0.465	+0.124	<.001	<.001	3	8
UCEC	IFT46 →	+0.465	+0.122	<.001	<.001	3	8
UCEC	TPPP3 →	+1.748	+0.136	<.001	<.001	3	7
UCEC	TTC21B →	+0.311	+0.100	<.001	<.001	3	7
BRCA	WDR19 →	+0.496	+0.053	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001578 vs WDR54 — UCEC

Explore this scatter interactively →