Microtubule bundle formation

Across TCGA patient cohorts, RNA activity of the Microtubule bundle formation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1B, APLP1, and TPST1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule bundle formation activity versus MAP1B in LSCC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+2.673	+1.768	<.001	.001	3	8
LUAD	APLP1 →	+1.123	+1.504	.002	.001	3	5
LUAD	TPST1 →	+0.723	+1.040	<.001	.002	3	5
UCEC	MIR4803 →	+2.827	+2.113	<.001	<.001	3	5
UCEC	EEPD1 →	+0.747	+1.430	.007	.008	3	5
CCRCC	CTIF →	+0.290	+0.831	.007	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001578 vs MAP1B — LSCC

Explore this scatter interactively →