Microtubule bundle formation

Across TCGA cell cohorts, RNA activity of the Microtubule bundle formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARRDC1, CREBL2, and MCFD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule bundle formation activity versus ARRDC1 in BLOOD_Leukemia (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ARRDC1 →	+0.900	+0.190	.001	<.001	3	4
LUNG_NSCLC_LUAD	CREBL2 →	+0.730	+0.276	<.001	<.001	3	4
LUNG_NSCLC_LUAD	MCFD2 →	+0.384	+0.154	.008	.003	3	4
OESOPHAGUS	HERC3 →	+1.292	+0.145	<.001	.008	3	4
BONE	ACTR6 →	-1.255	-0.311	.002	.003	3	4
LUNG_NSCLC_LUSC	PLXNA1 →	+1.801	+0.291	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001578 vs ARRDC1 — BLOOD_Leukemia

Explore this scatter interactively →