Ganglioside biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ganglioside biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST8SIA4, ST3GAL5, and RASAL3, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglioside biosynthetic process activity versus ST8SIA4 in ESCA (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	ST8SIA4 →	+0.840	+0.046	<.001	<.001	3	24
UCS	ST3GAL5 →	+1.544	+0.055	.001	.001	2	24
THYM	RASAL3 →	+1.146	+0.068	<.001	<.001	3	21
TGCT	JAK3 →	+0.709	+0.040	<.001	.001	3	21
ESCA	ARHGAP9 →	+0.983	+0.065	<.001	<.001	3	21
LGG	STAT4 →	+0.813	+0.025	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001574 vs ST8SIA4 — ESCA

Explore this scatter interactively →