Ganglioside biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ganglioside biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AK4P6, RETSAT, and MIR148B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglioside biosynthetic process activity versus AK4P6 in CCRCC (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AK4P6 →	+0.265	+0.212	.004	.001	3	3
PDAC	RETSAT →	+0.424	+0.922	.005	.008	3	3
BRCA	MIR148B →	-0.806	-0.143	.003	.009	3	2
OV	MPL →	+0.786	+0.306	<.001	<.001	3	2
PDAC	C16orf74 →	-0.750	-0.962	.003	.004	3	2
OV	RPS7 →	-1.179	-0.239	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001574 vs AK4P6 — CCRCC

Explore this scatter interactively →