Ganglioside biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ganglioside biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALNT1, ST3GAL2, and ORAI2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglioside biosynthetic process activity versus B4GALNT1 in URINARY_TRACT (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	B4GALNT1 →	+2.358	+0.115	<.001	.002	3	11
LUNG_NSCLC_LUSC	ST3GAL2 →	+1.731	+0.103	.001	<.001	3	11
LUNG_NSCLC_LUSC	ORAI2 →	+2.263	+0.098	.002	<.001	3	11
LUNG_NSCLC_LUSC	CHST12 →	+1.324	+0.110	<.001	<.001	3	11
OESOPHAGUS	ATP8B3 →	+1.740	+0.134	.007	.002	3	10
OESOPHAGUS	DLG4 →	+2.105	+0.132	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001574 vs B4GALNT1 — URINARY_TRACT

Explore this scatter interactively →