Ganglioside metabolic process

Across TCGA patient cohorts, RNA activity of the Ganglioside metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RENBP, ABI3, and GPRIN3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglioside metabolic process activity versus RENBP in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RENBP →	+0.503	+0.049	.004	.006	2	7
GBM	ABI3 →	+0.541	+0.053	<.001	<.001	3	6
LSCC	GPRIN3 →	+0.371	+0.041	.002	.001	3	6
LSCC	LCP2 →	+0.427	+0.043	<.001	.001	3	6
OV	ANKRD44 →	+0.405	+0.035	.002	<.001	3	6
COAD	PLEKHO2 →	+0.439	+0.033	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001573 vs RENBP — UCEC

Explore this scatter interactively →