Ganglioside metabolic process

Across TCGA patient cohorts, RNA activity of the Ganglioside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRBN, AK9, and TCAIM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglioside metabolic process activity versus CRBN in COAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CRBN →	-0.246	-0.158	.006	.006	2	4
COAD	AK9 →	-0.394	-0.219	<.001	<.001	3	3
GBM	TCAIM →	-0.385	-0.125	.003	.003	3	3
PDAC	RBMX2P3 →	-0.198	-0.165	.003	.001	3	3
PDAC	FGD5-AS1 →	-0.259	-0.194	.004	.001	3	3
COAD	BTF3P8 →	-0.377	-0.180	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001573 vs CRBN — COAD

Explore this scatter interactively →