Ganglioside metabolic process

Across TCGA cell cohorts, RNA activity of the Ganglioside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPOPL, NEK3, and TSPAN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPOPL grouped by Ganglioside metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SPOPL →	-0.746	-0.731	.001	.002	3	4
URINARY_TRACT	NEK3 →	+1.995	+2.073	.003	<.001	3	4
LUNG_NSCLC_LUSC	TSPAN1 →	+4.110	+0.953	.001	.007	3	3
SOFT_TISSUE	MYBBP1A →	-1.071	-1.097	.001	.009	3	3
SOFT_TISSUE	CTTN →	-1.321	-1.044	.001	.008	3	3
OVARY	IKBKB →	-0.899	-0.931	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPOPL by Ganglioside metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →