Ganglioside metabolic process

Across TCGA cell cohorts, RNA activity of the Ganglioside metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX9, MYBL2, and SDR9C7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHX9 grouped by Ganglioside metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DHX9 →	-0.416	-0.131	<.001	<.001	3	4
PANCREAS	MYBL2 →	-0.378	-0.077	<.001	.001	3	4
PANCREAS	SDR9C7 →	-0.101	-0.107	.006	.008	3	4
SOFT_TISSUE	GFOD1 →	-0.235	-0.146	.001	.001	3	4
LUNG_SCLC	DHX38 →	-0.510	-0.134	.003	.002	2	5
LUNG_SCLC	CLVS2 →	-0.466	-0.171	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHX9 by Ganglioside metabolic process activity — URINARY_TRACT

Explore this box plot interactively →