Ganglioside metabolic process

Across TCGA cell cohorts, RNA activity of the Ganglioside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEXB, CTSA, and TMED9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglioside metabolic process activity versus HEXB in BONE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HEXB →	+1.975	+1.681	<.001	<.001	3	7
LUNG_SCLC	CTSA →	+0.974	+1.073	<.001	<.001	3	7
BONE	TMED9 →	+1.429	+1.850	<.001	.003	3	7
BONE	LAMP1 →	+2.119	+2.242	.001	<.001	3	6
BONE	CBX2 →	-2.016	-1.924	<.001	<.001	3	6
BONE	SUMF1 →	+1.364	+1.822	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001573 vs HEXB — BONE

Explore this scatter interactively →