Vasculogenesis

Across TCGA patient cohorts, RNA activity of the Vasculogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, LAMA4, and LAMC1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasculogenesis activity versus KANK2 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KANK2 →	+0.628	+0.051	<.001	<.001	3	10
UCEC	LAMA4 →	+0.606	+0.045	<.001	<.001	3	10
HNSC	LAMC1 →	+0.635	+0.076	<.001	<.001	3	10
HNSC	NID1 →	+0.612	+0.060	<.001	<.001	3	10
BRCA	NID2 →	+0.493	+0.041	<.001	<.001	3	10
UCEC	PRKG1 →	+0.764	+0.054	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001570 vs KANK2 — UCEC

Explore this scatter interactively →