Vasculogenesis

Across TCGA patient cohorts, RNA activity of the Vasculogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RECK, ANXA5, and SGCD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasculogenesis activity versus RECK in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RECK →	+0.707	+0.307	.001	.004	3	5
LUAD	ANXA5 →	+0.390	+0.152	.003	<.001	3	5
BRCA	SGCD →	+0.754	+0.354	.009	.003	3	5
LUAD	MSRB3 →	+0.510	+0.111	.001	.003	3	5
LUAD	FAT4 →	+0.675	+0.145	.001	<.001	3	5
BRCA	IRAG1 →	+0.928	+0.323	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001570 vs RECK — BRCA

Explore this scatter interactively →