Vasculogenesis

Across TCGA cell cohorts, RNA activity of the Vasculogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS11, STX17, and ZNF182, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS11 grouped by Vasculogenesis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RPS11 →	+0.594	+0.715	.005	.006	3	4
LARGE_INTESTINE	STX17 →	+0.603	+0.806	.008	.005	3	4
SKIN	ZNF182 →	+0.482	+0.657	<.001	.003	3	4
LUNG_SCLC	MTRNR2L8 →	-0.572	-0.287	<.001	.009	3	3
LARGE_INTESTINE	TEC →	+0.789	+0.828	<.001	.003	3	3
LARGE_INTESTINE	PROSER2 →	+1.855	+0.644	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS11 by Vasculogenesis activity — OESOPHAGUS

Explore this box plot interactively →