Vasculogenesis

Across TCGA cell cohorts, RNA activity of the Vasculogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP19, SLC25A15, and TGFBI, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasculogenesis activity versus ARHGAP19 in BONE (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ARHGAP19 →	-2.232	-0.583	.002	<.001	3	7
LIVER	SLC25A15 →	-1.052	-0.404	.003	.003	3	6
LIVER	TGFBI →	+5.822	+0.485	.002	.004	2	7
LIVER	RPL10A →	-0.821	-0.465	.001	.008	3	6
BONE	FBL →	-0.798	-0.380	.003	.003	2	7
UPPER_AERODIGESTIVE_TRACT	NDUFB10 →	-0.694	-0.302	.007	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001570 vs ARHGAP19 — BONE

Explore this scatter interactively →