Response to protozoan

Across TCGA cell cohorts, RNA activity of the Response to protozoan pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBD6, SLX1B, and TAGLN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MBD6 grouped by Response to protozoan-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MBD6 →	-0.614	-0.767	.008	.002	3	4
KIDNEY	SLX1B →	+1.200	+1.060	.001	.003	3	3
SOFT_TISSUE	TAGLN →	-4.418	-1.275	.003	.006	3	3
SOFT_TISSUE	FZD5 →	-1.405	-0.896	.002	.005	3	3
SOFT_TISSUE	CNNM3 →	-0.651	-1.198	.001	.009	3	3
URINARY_TRACT	PLOD3 →	+0.792	+1.472	.006	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MBD6 by Response to protozoan activity — BREAST

Explore this box plot interactively →