Response to protozoan

Across TCGA cell cohorts, RNA activity of the Response to protozoan pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Mycophenolic acid, Pelitinib, and HKMTI-1-005, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Mycophenolic acid grouped by Response to protozoan-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Mycophenolic acid →	+0.675	+1.474	.037	.027	3	3
BLOOD_Leukemia	Pelitinib →	-1.505	-1.898	.002	.001	3	3
SKIN	HKMTI-1-005 →	+1.245	+2.182	.005	.007	2	3
BLOOD_Leukemia	Rapamycin →	+0.791	+1.036	.021	.017	3	2
BLOOD_Leukemia	EPZ004777 →	-0.442	-1.810	<.001	<.001	3	2
BLOOD_Leukemia	Bleomycin →	+0.437	+1.742	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Mycophenolic acid by Response to protozoan activity — BLOOD_Leukemia

Explore this box plot interactively →