Oocyte maturation

Across TCGA patient cohorts, RNA activity of the Oocyte maturation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPC_S397, ITGA5, and MMP14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oocyte maturation activity versus XPC_S397 in BRCA (Pearson r = -0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	XPC_S397 →	-0.455	-0.025	.001	.001	3	6
OV	ITGA5 →	+0.816	+0.057	<.001	<.001	3	6
OV	MMP14 →	+0.651	+0.061	<.001	<.001	3	6
LUAD	TACC3_S71 →	+0.946	+0.046	<.001	<.001	3	6
LUAD	OCIAD1_S108 →	+0.857	+0.057	<.001	<.001	3	6
LUAD	FBXO38_S654 →	-0.525	-0.035	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001556 vs XPC_S397 — BRCA

Explore this scatter interactively →