Oocyte maturation

Across TCGA patient cohorts, RNA activity of the Oocyte maturation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPT, MRPL38, and NDUFB8P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oocyte maturation activity versus GAPT in LSCC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GAPT →	-0.697	-0.698	.001	<.001	3	4
BRCA	MRPL38 →	-0.396	-0.489	<.001	<.001	3	4
BRCA	NDUFB8P2 →	-0.574	-0.498	.005	.006	3	4
UCEC	VAV1 →	-0.756	-0.233	.005	.006	3	3
LSCC	JAML →	-0.794	-0.577	<.001	.002	3	3
UCEC	LAIR1 →	-0.610	-0.275	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001556 vs GAPT — LSCC

Explore this scatter interactively →