Oocyte maturation

Across TCGA cell cohorts, RNA activity of the Oocyte maturation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRRM2, RSRC2, and ZNF665, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRRM2 grouped by Oocyte maturation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SRRM2 →	-0.441	-0.203	.009	.005	3	4
URINARY_TRACT	RSRC2 →	+0.559	+0.317	.005	.007	3	4
OVARY	ZNF665 →	+1.172	+0.282	.005	.006	3	4
BREAST	CPT2 →	-0.690	-0.456	.001	.005	3	4
BREAST	SUPT3H →	+0.762	+0.354	.002	.006	3	4
PANCREAS	YTHDC2 →	+0.578	+0.210	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRRM2 by Oocyte maturation activity — LUNG_SCLC

Explore this box plot interactively →