Luteolysis

Across TCGA patient cohorts, RNA activity of the Luteolysis pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOTCH1, NOTCH3, and SLIT3, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Luteolysis activity versus NOTCH1 in SCLC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	NOTCH1 →	+1.204	+0.687	<.001	<.001	3	26
TGCT	NOTCH3 →	+1.346	+0.109	<.001	<.001	3	23
PAAD	SLIT3 →	+1.854	+0.117	<.001	<.001	3	22
THYM	KMT2E →	+0.898	+0.059	<.001	<.001	3	22
MESO	KMT2C →	+0.861	+0.094	<.001	<.001	3	22
TGCT	GLI3 →	+1.570	+0.104	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001554 vs NOTCH1 — SCLC

Explore this scatter interactively →