Luteolysis

Across TCGA patient cohorts, RNA activity of the Luteolysis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SVEP1, SGCD, and SARM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Luteolysis activity versus SVEP1 in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SVEP1 →	+0.650	+0.071	.001	<.001	3	7
CCRCC	SGCD →	+0.631	+0.106	<.001	<.001	3	7
LSCC	SARM1 →	+0.456	+0.082	<.001	.003	3	6
LSCC	SLIT2 →	+0.543	+0.106	<.001	<.001	3	6
OV	COL15A1 →	+0.516	+0.068	<.001	<.001	3	6
LUAD	KANK2 →	+0.349	+0.086	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001554 vs SVEP1 — OV

Explore this scatter interactively →