Luteolysis

Across TCGA cell cohorts, RNA activity of the Luteolysis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOTCH1, CASP2, and SLIT2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOTCH1 grouped by Luteolysis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NOTCH1 →	-0.294	-1.460	<.001	<.001	3	9
CNS	CASP2 →	-0.252	-1.721	<.001	<.001	3	9
CNS	SLIT2 →	-0.328	-1.231	<.001	<.001	3	9
CNS	AGBL3 →	-0.305	-1.520	.003	<.001	3	6
BREAST	CASP3 →	-0.167	-1.026	<.001	<.001	3	6
BLOOD_Leukemia	EXOC2 →	-0.202	-1.262	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOTCH1 by Luteolysis activity — BLOOD_Leukemia

Explore this box plot interactively →