Luteolysis

Across TCGA cell cohorts, RNA activity of the Luteolysis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOTCH1, CASP2, and FAM53B, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Luteolysis activity versus NOTCH1 in OESOPHAGUS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NOTCH1 →	+1.564	+0.228	<.001	<.001	3	14
BONE	CASP2 →	+1.185	+0.219	<.001	<.001	3	12
URINARY_TRACT	FAM53B →	+1.208	+0.195	<.001	<.001	2	10
BLOOD_Myeloma	NOM1 →	+0.927	+0.169	.001	.003	3	9
BONE	PAXIP1 →	+1.137	+0.199	<.001	<.001	3	9
BLOOD_Leukemia	ZSCAN25 →	+0.995	+0.211	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001554 vs NOTCH1 — OESOPHAGUS

Explore this scatter interactively →