Luteolysis

Across TCGA cell cohorts, RNA activity of the Luteolysis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD4, SSR3, and LMBR1L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Luteolysis activity versus CHD4 in BREAST (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CHD4 →	+0.636	+1.672	.005	<.001	3	3
BREAST	SSR3 →	-1.170	-1.450	<.001	.001	3	3
BREAST	LMBR1L →	+1.321	+1.672	<.001	<.001	3	3
BREAST	ZBTB39 →	+1.160	+1.501	.002	.002	3	3
BREAST	CDK12 →	+0.403	+1.672	<.001	<.001	3	3
BREAST	ZNF322 →	+1.164	+1.357	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001554 vs CHD4 — BREAST

Explore this scatter interactively →