Luteinization

Across TCGA patient cohorts, RNA activity of the Luteinization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCAR, DACT1, and SPATA20P1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Luteinization activity versus FCAR in LUAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FCAR →	+0.474	+0.204	.004	.001	3	6
LUAD	DACT1 →	+0.614	+0.182	<.001	<.001	3	5
LUAD	SPATA20P1 →	+0.947	+0.226	<.001	<.001	3	5
LUAD	GK-AS1 →	+0.501	+0.165	.006	.004	3	5
HNSC	CEACAM3 →	+0.366	+0.098	.008	.006	3	5
BRCA	ARSI →	+0.721	+0.262	.002	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001553 vs FCAR — LUAD

Explore this scatter interactively →