Luteinization

Across TCGA cell cohorts, RNA activity of the Luteinization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC75A, NCDN, and KIAA1958, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRC75A grouped by Luteinization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LRRC75A →	-0.932	-1.744	<.001	.001	3	5
LARGE_INTESTINE	NCDN →	+0.857	+1.287	.004	.004	3	4
SOFT_TISSUE	KIAA1958 →	-0.940	-1.089	<.001	.002	3	4
SOFT_TISSUE	TMEM170B →	-1.444	-1.432	.005	.001	3	4
SOFT_TISSUE	CGREF1 →	+3.146	+1.414	.004	.002	3	4
PANCREAS	GABARAP →	-0.991	-1.177	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRC75A by Luteinization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →