Ovulation from ovarian follicle

Across TCGA patient cohorts, RNA activity of the Ovulation from ovarian follicle pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GUCY1A1, CNRIP1, and TNS1_S1588, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ovulation from ovarian follicle activity versus GUCY1A1 in UCEC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUCY1A1 →	+0.390	+0.064	<.001	.004	3	6
UCEC	CNRIP1 →	+0.625	+0.063	<.001	.005	3	5
UCEC	TNS1_S1588 →	+1.017	+0.107	.001	<.001	3	5
LSCC	SIRT1_S27 →	+0.420	+0.048	<.001	.001	3	5
CCRCC	TBX2_S676 →	+0.599	+0.076	.001	.001	3	5
CCRCC	TNS2_S102 →	+0.483	+0.072	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001542 vs GUCY1A1 — UCEC

Explore this scatter interactively →