Ovulation from ovarian follicle

Across TCGA patient cohorts, RNA activity of the Ovulation from ovarian follicle pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP4, KCNK6, and SEMA6C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ovulation from ovarian follicle activity versus IGFBP4 in BRCA (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGFBP4 →	+0.683	+0.609	.001	<.001	3	4
BRCA	KCNK6 →	+0.738	+0.611	<.001	<.001	3	4
CCRCC	SEMA6C →	+0.549	+0.631	<.001	.002	3	4
OV	TRPC6 →	+0.674	+0.667	.001	.003	3	3
BRCA	RGS11 →	+0.882	+0.593	<.001	<.001	3	3
BRCA	CD99L2 →	+0.400	+0.514	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001542 vs IGFBP4 — BRCA

Explore this scatter interactively →