Ovulation from ovarian follicle

Across TCGA cell cohorts, RNA activity of the Ovulation from ovarian follicle pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD320, ZNF7, and HCCS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD320 grouped by Ovulation from ovarian follicle-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CD320 →	+0.370	+0.146	.002	.001	3	4
OVARY	ZNF7 →	-0.224	-0.847	.005	.008	3	3
BLOOD_Myeloma	HCCS →	-0.336	-0.114	.007	.009	3	3
CNS	FREM2 →	-0.219	-0.144	.002	.007	3	3
LUNG_SCLC	ARF4 →	+0.181	+1.363	.009	.004	2	4
LUNG_SCLC	SLC18A3 →	-0.172	-1.287	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD320 by Ovulation from ovarian follicle activity — BLOOD_Myeloma

Explore this box plot interactively →