Ovarian follicle development

Across TCGA patient cohorts, RNA activity of the Ovarian follicle development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTX3, TTC39B, and SCG5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ovarian follicle development activity versus PTX3 in COAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PTX3 →	+0.535	+0.208	.001	.001	3	5
PDAC	TTC39B →	-0.226	-0.123	.003	.001	3	4
PDAC	SCG5 →	+0.924	+0.175	.003	.001	3	4
BRCA	STC1 →	+1.352	+0.135	<.001	<.001	3	4
BRCA	NUDT8 →	-0.870	-0.137	.002	.006	3	4
BRCA	STC2 →	+1.754	+0.168	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001541 vs PTX3 — COAD

Explore this scatter interactively →