Ovarian follicle development

Across TCGA cell cohorts, RNA activity of the Ovarian follicle development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PER3, EIF5A2, and KCNE3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PER3 grouped by Ovarian follicle development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PER3 →	+0.470	+1.171	.007	.008	3	3
BLOOD_Leukemia	EIF5A2 →	+0.333	+1.864	.002	<.001	3	3
BLOOD_Leukemia	KCNE3 →	-0.108	-1.455	.006	.001	3	3
BLOOD_Myeloma	TOX2 →	+0.360	+1.673	.007	.002	3	3
UPPER_AERODIGESTIVE_TRACT	GABRR1 →	+0.160	+0.385	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	UBBP4 →	-0.318	-0.385	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PER3 by Ovarian follicle development activity — LUNG_SCLC

Explore this box plot interactively →