Ovarian follicle development

Across TCGA cell cohorts, RNA activity of the Ovarian follicle development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBBP1A, PGAM4, and EIF5AL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ovarian follicle development activity versus MYBBP1A in SOFT_TISSUE (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MYBBP1A →	-1.023	-1.443	.001	<.001	3	6
OVARY	PGAM4 →	-0.568	-1.212	.007	.001	3	6
SOFT_TISSUE	EIF5AL1 →	-1.171	-1.648	.004	<.001	3	5
SOFT_TISSUE	UBE2G1 →	-0.546	-1.001	.001	.008	3	5
SOFT_TISSUE	PFAS →	-0.967	-1.215	.002	<.001	3	5
SOFT_TISSUE	DHX33 →	-0.643	-1.303	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001541 vs MYBBP1A — SOFT_TISSUE

Explore this scatter interactively →