Cilium or flagellum-dependent cell motility

Across TCGA patient cohorts, RNA activity of the Cilium or flagellum-dependent cell motility pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LZTFL1, WDR19, and WDR35, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cilium or flagellum-dependent cell motility activity versus LZTFL1 in BRCA (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LZTFL1 →	+0.600	+0.030	<.001	<.001	3	8
UCEC	WDR19 →	+0.498	+0.117	<.001	<.001	3	7
UCEC	WDR35 →	+0.509	+0.114	<.001	<.001	3	7
UCEC	WDR54 →	+0.646	+0.112	<.001	<.001	3	7
UCEC	CETN2 →	+0.541	+0.104	<.001	<.001	3	7
OV	DNALI1 →	+0.874	+0.049	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001539 vs LZTFL1 — BRCA

Explore this scatter interactively →