Cilium or flagellum-dependent cell motility

Across TCGA cell cohorts, RNA activity of the Cilium or flagellum-dependent cell motility pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR76, TTC27, and ETFDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cilium or flagellum-dependent cell motility activity versus WDR76 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	WDR76 →	+1.147	+0.465	.003	.001	3	6
OVARY	TTC27 →	+0.464	+0.470	.001	<.001	2	6
STOMACH	ETFDH →	+0.720	+0.455	.007	<.001	3	5
LIVER	PCBP1 →	+0.648	+0.399	.008	.001	3	5
BLOOD_Myeloma	KHSRP →	+0.658	+0.204	.003	.007	3	5
UPPER_AERODIGESTIVE_TRACT	DTD2 →	+1.084	+0.521	.008	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001539 vs WDR76 — UPPER_AERODIGESTIVE_TRACT

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