Pseudouridine synthesis

Across TCGA patient cohorts, RNA activity of the Pseudouridine synthesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAF7, MYBL2, and RAB8B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pseudouridine synthesis activity versus TRAF7 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRAF7 →	+0.393	+0.109	<.001	.006	3	5
LSCC	MYBL2 →	+0.679	+0.192	<.001	<.001	3	5
LUAD	RAB8B →	-0.375	-0.144	.002	.003	3	5
LSCC	ZNF598 →	+0.545	+0.258	<.001	<.001	3	5
LUAD	GNG12 →	-0.542	-0.152	<.001	<.001	3	5
LUAD	LINC01936 →	-0.573	-0.145	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001522 vs TRAF7 — LSCC

Explore this scatter interactively →