Pseudouridine synthesis

Across TCGA cell cohorts, RNA activity of the Pseudouridine synthesis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX24, TRIP10, and FBRSL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pseudouridine synthesis activity versus SNX24 in SKIN (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SNX24 →	-1.319	-0.916	<.001	.002	3	4
BLOOD_Lymphoma	TRIP10 →	-1.833	-0.211	.005	.002	3	4
KIDNEY	FBRSL1 →	+1.607	+1.237	.004	.006	2	5
KIDNEY	JOSD2 →	-1.093	-1.416	<.001	.001	3	4
BREAST	S100A6 →	-2.771	-0.617	.002	.009	2	5
BLOOD_Myeloma	SPATA21 →	-0.073	-0.202	.008	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001522 vs SNX24 — SKIN

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