RNA methylation

Across TCGA patient cohorts, RNA activity of the RNA methylation pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FKTN, FNBP4, and CPSF6, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA methylation activity versus FKTN in UVM (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	FKTN →	+1.415	+0.063	<.001	<.001	3	34
UVM	FNBP4 →	+1.786	+0.062	<.001	<.001	3	34
UVM	CPSF6 →	+1.074	+0.055	<.001	<.001	3	34
UVM	MED23 →	+1.205	+0.051	<.001	<.001	3	34
UVM	NKTR →	+1.719	+0.066	<.001	<.001	3	34
UVM	DNAJC27 →	+1.295	+0.061	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001510 vs FKTN — UVM

Explore this scatter interactively →