RNA methylation

Across TCGA patient cohorts, RNA activity of the RNA methylation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPM2AIP1, SLC16A3_S436, and SND1_S645, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA methylation activity versus EPM2AIP1 in COAD (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EPM2AIP1 →	+0.345	+0.013	<.001	.002	3	6
UCEC	SLC16A3_S436 →	-0.787	-0.069	.002	<.001	3	6
HNSC	SND1_S645 →	-0.760	-0.081	<.001	<.001	3	6
HNSC	HDLBP_S944 →	-0.390	-0.048	<.001	.004	3	6
UCEC	RPRD2_T732 →	+0.317	+0.076	.001	<.001	3	5
LSCC	BRD8 →	+0.369	+0.036	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001510 vs EPM2AIP1 — COAD

Explore this scatter interactively →