RNA methylation

Across TCGA patient cohorts, RNA activity of the RNA methylation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOLC1, PRPF4B_S294, and NOLC1_S538, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA methylation activity versus NOLC1 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NOLC1 →	+0.624	+0.242	<.001	<.001	3	9
OV	PRPF4B_S294 →	+0.794	+0.175	<.001	.001	3	9
OV	NOLC1_S538 →	+0.798	+0.187	<.001	<.001	3	9
GBM	SAFB →	+0.410	+0.389	<.001	<.001	3	8
OV	SNRNP200 →	+0.232	+0.203	.001	.001	2	9
OV	SNRNP70 →	+0.556	+0.162	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001510 vs NOLC1 — OV

Explore this scatter interactively →