Action potential

Across TCGA patient cohorts, RNA activity of the Action potential pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRB3, PKP2, and TIMELESS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Action potential activity versus MSRB3 in BRCA (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MSRB3 →	+0.723	+0.456	<.001	.001	3	4
UCEC	PKP2 →	+0.951	+0.419	<.001	<.001	3	4
COAD	TIMELESS →	-0.617	-0.996	.002	.006	3	4
HNSC	ARHGAP30 →	-0.865	-0.283	<.001	.001	3	4
LSCC	SLA2 →	-1.106	-0.384	.003	.001	3	4
UCEC	PTPRK-AS1 →	+0.916	+0.339	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001508 vs MSRB3 — BRCA

Explore this scatter interactively →