Action potential

Across TCGA cell cohorts, RNA activity of the Action potential pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIN28B, UGT1A6, and CTNNA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LIN28B grouped by Action potential-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LIN28B →	+0.231	+1.011	.008	.008	3	5
UPPER_AERODIGESTIVE_TRACT	UGT1A6 →	+0.121	+0.142	.003	.002	3	4
SKIN	CTNNA3 →	-0.149	-0.750	.006	.003	3	4
UPPER_AERODIGESTIVE_TRACT	SLC25A18 →	-0.186	-0.180	.006	.009	2	4
CNS	TP53 →	-0.517	-0.577	.003	.007	3	3
OESOPHAGUS	MS4A6E →	-0.292	-0.175	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIN28B by Action potential activity — KIDNEY

Explore this box plot interactively →