Action potential

Across TCGA cell cohorts, RNA activity of the Action potential pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A17, RBX1, and ZC3H7B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A17 grouped by Action potential-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC25A17 →	+0.715	+0.664	<.001	.002	3	4
LARGE_INTESTINE	RBX1 →	+0.518	+0.674	<.001	<.001	3	3
LARGE_INTESTINE	ZC3H7B →	+0.653	+0.674	.004	.003	3	3
LARGE_INTESTINE	POLR3H →	+0.712	+0.667	.002	.002	3	3
LARGE_INTESTINE	MND1 →	+0.726	+0.830	.005	.004	3	3
LARGE_INTESTINE	YWHAH →	+0.810	+0.920	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A17 by Action potential activity — LARGE_INTESTINE

Explore this box plot interactively →