Action potential

Across TCGA cell cohorts, RNA activity of the Action potential pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCC3, SIRT5, and HNRNPC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCC3 grouped by Action potential-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ABCC3 →	-0.257	-0.082	<.001	.004	3	5
OVARY	SIRT5 →	-0.093	-0.066	.007	.005	3	5
BREAST	HNRNPC →	-0.454	-0.101	.003	.005	3	5
LUNG_NSCLC_LUSC	VGLL1 →	+0.216	+0.066	<.001	.001	3	4
BONE	ITGAV →	-0.842	-0.088	.006	<.001	2	5
BREAST	ZFP36L1 →	-0.237	-0.117	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCC3 by Action potential activity — OVARY

Explore this box plot interactively →