Action potential

Across TCGA cell cohorts, RNA activity of the Action potential pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP3, LGALS3, and TRIOBP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Action potential activity versus GBP3 in SKIN (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GBP3 →	+1.566	+0.278	.008	.009	3	6
SOFT_TISSUE	LGALS3 →	+2.862	+0.247	.001	.003	3	6
OVARY	TRIOBP →	+0.811	+0.301	.002	.003	2	7
OESOPHAGUS	RASL10B →	-1.851	-0.431	.008	.001	3	6
STOMACH	LAMTOR3 →	+0.659	+0.247	.009	.008	3	5
STOMACH	RAB6B →	-2.197	-0.413	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001508 vs GBP3 — SKIN

Explore this scatter interactively →