Neurotransmitter uptake

Across TCGA patient cohorts, RNA activity of the Neurotransmitter uptake pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL1A1, SFRP2, and SGCD, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter uptake activity versus COL1A1 in COAD (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COL1A1 →	-0.680	-0.033	.001	.004	3	7
OV	SFRP2 →	-1.721	-0.058	<.001	<.001	3	6
OV	SGCD →	-0.767	-0.058	<.001	<.001	3	6
OV	CNN2 →	-0.965	-0.060	<.001	<.001	3	6
COAD	COL1A2 →	-0.644	-0.037	.002	.002	3	6
OV	COL3A1 →	-0.699	-0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001504 vs COL1A1 — COAD

Explore this scatter interactively →