Neurotransmitter uptake

Across TCGA patient cohorts, RNA activity of the Neurotransmitter uptake pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMG2, PCDH10, and HOXC8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter uptake activity versus PSMG2 in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSMG2 →	-0.192	-0.285	.005	<.001	3	4
GBM	PCDH10 →	+0.721	+0.320	<.001	<.001	3	3
CCRCC	HOXC8 →	-0.590	-0.752	<.001	<.001	3	3
BRCA	RPL21P119 →	-0.622	-0.551	.002	.006	3	3
GBM	DSC1 →	+0.180	+0.299	<.001	.003	3	3
GBM	ACKR2 →	+0.219	+0.287	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001504 vs PSMG2 — GBM

Explore this scatter interactively →