Neurotransmitter uptake

Across TCGA cell cohorts, RNA activity of the Neurotransmitter uptake pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALAD, RNF144B, and SOGA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter uptake activity versus ALAD in OVARY (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ALAD →	+1.067	+0.753	.001	.004	3	4
BLOOD_Lymphoma	RNF144B →	+3.262	+0.264	<.001	.001	3	4
LARGE_INTESTINE	SOGA1 →	+1.222	+0.763	<.001	<.001	3	4
OVARY	RAB11FIP4 →	+3.430	+1.042	.002	.009	2	4
OVARY	SSC5D →	+1.101	+1.126	.006	.008	3	3
LUNG_SCLC	MRPL45 →	-0.782	-0.426	.002	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001504 vs ALAD — OVARY

Explore this scatter interactively →