Guanine nucleotide transport

Across TCGA patient cohorts, RNA activity of the Guanine nucleotide transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIPOR1, AIF1, and ITGA4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Guanine nucleotide transport activity versus RIPOR1 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIPOR1 →	+0.204	+0.058	.001	<.001	3	7
GBM	AIF1 →	+1.027	+0.064	<.001	<.001	3	7
CCRCC	ITGA4 →	+0.375	+0.076	<.001	<.001	3	7
BRCA	RCSD1 →	+0.462	+0.057	.001	<.001	3	6
GBM	ARRB2 →	+0.335	+0.053	<.001	<.001	3	6
CCRCC	SAMSN1 →	+0.450	+0.066	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001408 vs RIPOR1 — LSCC

Explore this scatter interactively →